Webwww.ncbi.nlm.nih.gov Web8 Sep 2024 · The cancer cells were either exposed to EGFR inhibitors only or to a combination of EGFR and SOS1 inhibitors. The most effective treatment was found to be through combinational therapy, with enhanced killing of drug-resistant cells. ... (2024) SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition …
Therapeutic potential of SHOC2 via its selective contribution of …
Web1 Jul 2024 · SHOC2 is a scaffolding protein that facilitates RAS signaling by binding to RAS, RAS effectors (RAF1/PI3K) and other downstream regulators. Based on our findings, we hypothesize that SHOC2 is a novel, potent target to sensitize KRAS mutant pancreatic cancer cells to MEK inhibitors through mechanisms downstream of RAS signaling. WebGlioblastoma multiforme (GBM) is an aggressive type of brain tumor where . 3% of newly diagnosed cases in the patients will survive >5 years.. In adults, GBM is the most common type of brain tumor. It is rarer in children, where it constitutes approximately 15% of all brain tumors diagnosed. nist 800-60 and reference table c-1
Elucidating the role of SHOC2 to enhance MEK inhibitor sensitivity …
Web5 Nov 2024 · The immunoprecipitates were analyzed by immunoblotting using anti-Ub and -Shoc2 antibodies. Cell lysates were analyzed using anti-USP7, -Ub and -Shoc2 antibodies. … Web4 Feb 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and … WebThe extracellular signal-regulated kinase (ERK1/2) cascade regulates a myriad of functions in multicellular organisms. Scaffold proteins provide critical spatial and temporal control … nurse giving shot image