Web25 Mar 2013 · It has also been reported to dampen ERK by binding and inhibiting the scaffolding function of SHOC2, ... Sections were blocked in 2% BSA/10% normal goat serum/PBS for 30 minutes at 37°C or overnight at 4°C. Goat serum was omitted when primary antibodies included goat IgG. Primary antibody incubation was carried out … Webdependent manner. SHOC2-independent mechanisms of ERK activation involving CRAF activation by N-region phosphorylation make SHOC2 redundant for normal proliferation in 2D and likely account for tissue homeostasis in adult mice. However, oncogenic KRAS signalling favours SHOC2-mediated ERK activation, which is
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WebNoonan and Noonan-related syndromes are common autosomal dominant disorders with neuro-cardio-facial-cutaneous and developmental involvement. The objective of this article is to describe the most relevant tegumentary findings in a cohort of 41 Web16 Oct 2024 · MO knockdown of shoc2. To explore the function of Shoc2 during embryogenesis, we first used two different translation-blocking morpholino antisense (MO) oligonucleotides to inhibit expression of shoc2 at early stages of development ().The effectiveness of gene knockdown by these translation-blocking MOs was confirmed by … rowley diary of wimpy kid movie
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Web24 Nov 2024 · Aim: To explore the roles of lncRNA MALAT1 and SHOC2 in breast cancer, and the potential connections to chemotherapy resistance in breast cancer. Materials & methods: Paclitaxel-resistant breast cancer cells were induced by gradually increasing intermittent doses. Bioinformatic analyses were performed to predict the regulated … WebSHOC2. AU017287, Sur8, mKIAA0862. soc-2 (suppressor of clear) homolog (C. elegans) GO Process (1) GO Function (1) GO Component (4) Gene Ontology Biological Process. positive regulation of Ras protein signal transduction . Gene Ontology Molecular Function. protein phosphatase binding . Web1 Dec 2015 · The scaffold protein Shoc2 tethers Ras, RAF-1 and the catalytic subunit of protein phosphatase 1c (PP1c, also known as PPP1CA) to accelerate ERK1/2 signals (Rodriguez-Viciana et al., 2006).Silencing of Shoc2 expression leads to a dramatic decrease in ERK1/2 activity in a myriad of cells and in C. elegans (Rodriguez-Viciana et al., 2006; … rowley curtain rods