Protein lactylation
Webb4 apr. 2024 · National Center for Biotechnology Information Webb20 maj 2024 · The lactylated proteins were distributed in multiple subcellular compartments and were closely related to a wide variety of biological processes, including mRNA splicing, glycolysis, aminoacyl-tRNA biosynthesis, RNA transport, and multiple signaling pathways.
Protein lactylation
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Webb23 okt. 2024 · Discovery of a label derived from lactate molecules reveals a way in which cells link gene expression to nutrient metabolism. Lactylation is a newly discovered … Webb27 nov. 2024 · Lactylation is a newly found lactate-derived post-translational modification, which is firstly reported on histone protein lysine residues to regulate gene …
Webb12 okt. 2024 · This study may open an avenue for the exploration of a role of neuronal activity-induced lactate mediated by protein lactylation in the brain. Kla induced by exogenous lactate in brain cells ... Webb26 aug. 2024 · Yang et al. found that the nuclear protein Hmgb1 can be directly lactylated in a p300/CBP-dependent mechanism upon lactate stimulation, which led to its …
Webb26 okt. 2024 · The lactylated proteins were distributed in multiple compartments and associated with diversified biological processes, which do not have obvious roles in DNA-templated process. Besides, we identified 82 lactylation sites in 43 ribosomal proteins, indicating that Kla is an abundant PTM in the ribosome.
Webb15 mars 2024 · In this study, lactylation data for rice were collected from literature as training data . The annotated lactylation sites on lysine (K) were used as positive data, …
Webb12 okt. 2024 · Protein lactylation is induced in the brain by neural activation and social stress by Fujita Health University This paper shows that protein lactylation in brain cells … ten pin bowling offers vouchersWebb6 jan. 2024 · Lactylation is an all-protein post-translational modification occurring in both healthy subjects and critically ill patients. H3K18la may reflect the severity of critical … triangle car park southampton pricesWebbLactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects. An-Na Chen †, Yan Luo †, Yu-Han Yang, Jian-Tao Fu, Xiu-Mei Geng, Jun-Ping Shi * and Jin Yang *. Department of Translational Medicine Center, Affiliated Hospital of Hangzhou Normal University, Institute of Hepatology and Metabolic Diseases, Hangzhou Normal ... tenpin bowling north shore aucklandWebb12 okt. 2024 · Protein lactylation, a novel post-translational modification, is induced in the brain by neural activation and social stress Peer-Reviewed Publication Fujita Health … ten pin bowling in farnboroughWebb21 dec. 2024 · Background Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently, lactylation has been reported as a novel epigenetic modification that regulates various cellular processes, but its role during early embryogenesis has not … triangle caseworkWebb12 okt. 2024 · This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, whether Kla is induced by the stimuli that accompany changes in lactate levels. Here, we show that Kla in brain cells is regulated by neural excitation and social stress, with parallel ... ten pin bowling northwichWebb10 juni 2024 · Abstract. Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a … triangle car service durham nc