Mitomycin renal toxicity
WebNone of the other patients developed renal toxicity, while all laboratory tests remained within normal ranges. All available literature on this subject was also reviewed. Based on … WebSuppressed renal or hepatic function. Interfere with drug metabolism and excretion. Adverse Effects. Use of alkylating agents may result to these adverse effects: GI: nausea, vomiting, anorexia, diarrhea, and mucous membrane deterioration, hepatic toxicity; GU: renal toxicity, potentially toxic increase in uric acid levels
Mitomycin renal toxicity
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WebKuroda K, Teranishi S, Akao M (1982) Toxicity of Mitomycin C and anti-intoxication by fumaric acid in liver and kidney cellular fine structure. Gann 73:656–660. Google Scholar Le Hir M, Dubach UC, Schmidt U (1979) Quantitative distribution of lysosomal hydrolases in the rat nephron. Histochemistry 63:245–251 WebWe analyzed adverse events by comparing the proportion of grade 3 or 4 adverse events using a stratified Mantel–Haenszel test. To avoid interpreting disease symptoms as side effects, late...
WebA quinone-containing anticancer drug, named Mitomycin c (MMC), is known to redox cycle and generates reactive oxygen species. The MMC's topical application is a treatment choice for those whose surgery cannot be done to them and those with postoperative restenosis. WebStathopoulos et al tested lipoplatin – a liposomal cisplatin aimed at the avoidance of renal toxicity – combined with gemcitabine in pretreated patients with advanced pancreatic cancer. 34 The objective response rate data showed a partial response in two of the 24 patients examined (8.3%) and stable disease in 14 patients (58.3%).
Web26 jul. 2015 · Grade 3–4 leucopenia was observed in four (12.9%) and grade 3–4 anemia in three (9.7%). No patients had renal toxicity resulting from MM. All toxicity was manageable. Dose reduction was necessary in seven (22.6%) patients mainly due to hematological toxicity (Table 3). Renal toxicity, hemolytic uremic syndrome (HUS), was … Web1 feb. 1987 · Renal toxicity in man treated with mitomycin C. Cancer 1971, 28, 1314-1320. Verwey J, Burg MEL van der, Pinedo HM. Six cases of mitomycin C-induced hemolytic …
WebDRUG NAME: Mitomycin SYNONYM(S): mitomycin C,1 MMC2. COMMON TRADE NAME(S): MUTAMYCIN® CLASSIFICATION: antitumour antibiotic. Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Mitomycin is derived from Streptomyces caespitosus 3 and has …
Web*Graded per National Cancer Institute Common Terminology Criteria for Adverse Events. Version 5.0 (NCI CTCAE v5). † Includes flank pain and back pain. ‡ Includes hematuria … how to check my ward numberWebEmbryo-Fetal Toxicity 6 ADVERSE REACTIONS . 6.1 Clinical Trials Experience . 8 USE IN SPECIFIC POPULATIONS 8.1 . Pregnancy 8.2 . Lactation 8.3 . Females and Males of … how to check my water pressureWebRenal Toxicity Patients receiving mitomycin should be observed for evidence of renal toxicity. Mitomycin should not be given to patients with a serum creatinine greater than … how to check my waypoint in pubg xboxWebmechanisms of nephrotoxicity. Effects of mycotoxins on the kidney Morphology. A number of studies have been un-dertaken wherein possible alterations of renal struc-ture in … how to check my webpack versionWeb30 nov. 2024 · As with many other chemotherapeutic agents, most of the adverse effects of mitomycin are dose-related, including myelosuppression (which is typically delayed in … how to check my wassce resultWeb6 sep. 2024 · Patients receiving mitomycin should be observed for evidence of renal toxicity. Mitomycin should not be given to patients with a serum creatinine greater than … how to check my website hostWeb1 mei 2015 · The results showed that rhEPO treatment restored body weight, organs weight, and organs ratio as well as serum biochemical parameters and histological damage caused by MMC exposure. Mitomycin C (MMC) is one of the most effective chemotherapeutic drugs. However, the dose of MMC is greatly limited by its toxicity in normal tissues. … how to check my weight