Witryna13 sty 2024 · IMpower133 (ClinicalTrials.gov identifier: NCT02763579 ), a randomized, double-blind, phase I/III study, demonstrated that adding atezolizumab (anti-programmed death-ligand 1 [PD-L1]) to carboplatin plus etoposide (CP/ET) for first-line (1L) treatment of extensive-stage small-cell lung cancer (ES-SCLC) resulted in significant … Witryna20 lut 2015 · This randomized Phase III, multicenter, open-label study designed to evaluate the safety and efficacy of atezolizumab (an engineered anti-programmed …
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Witryna22 paź 2024 · Overall, IMpower130 showed statistically significant, clinically meaningful improvements in OS and statistically significant improvements in PFS with atezo + CnP, vs CnP, in 1L, stage IV non-squamous NSCLC, in this predominantly ITT-WT population. No new safety signals were identified. Clinical trial identification NCT02367781 (20 … WitrynaBased on findings from IMpassion130, international guidelines now recommend atezolizumab (A) + nab-paclitaxel (nP) for patients (pts) with locally advanced or … jci sandton
Carboplatin, nab-paclitaxel plus atezolizumab in IMpower …
WitrynaEfficacy was evaluated in IMpower130 (NCT02367781), a multicenter, randomized (2:1), open-label trial in patients with stage IV non-squamous NSCLC who had received no prior chemotherapy for ... WitrynaBackground. The Phase III IMpower132 study, evaluating first line pemetrexed plus carboplatin/cisplatin with or without atezolizumab in Stage IV non-squamous NSCLC without EGFR or ALK driver mutations, has met its PFS endpoint with an HR of 0.60 (95% CI: 0.49, 0.72; P . 0.0001; Papadimitrakopoulou, WCLC 2024).. Here we … WitrynaIn the randomised, Ph III IMpower150 study, first-line treatment (tx) with A + B + carboplatin and paclitaxel (CP) significantly prolonged PFS and OS compared with B … jci sdgs