Gpr146 cell research
WebApr 13, 2024 · Obesity has multiplied in the past few decades worldwide and will continue to rise in most countries, which leads to huge direct and indirect healthcare costs for more than $700 billion each year.... WebGPR146 is expressed in three C-peptide-responsive cells lines and appears to be essential for C-peptide-induced cFos expression in KATOIII cells. Furthermore, knockdown of GPR146 reduced FBS-induced cFos expression, indicating that GPR146 is essential for transmitting the signal of a factor present in FBS, such as C-peptide.
Gpr146 cell research
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WebNov 27, 2024 · In line with human genetic findings showing that increased expression of GPR146 is associated with elevated plasma TC levels, plasma TC levels were significantly reduced by 20% in male and by 25% in female Gpr146−/− mice fed chow compared to Gpr146+/+ littermates (16 h fasted, 16-week old male: 63.9 ± 7.3 mg/dl versus 80.4 ± 6.8 … WebG-protein-coupled receptors (GPCRs) comprise the largest human membrane receptor family, relay environmental stimuli to essential changes in cell behavior and represent prime drug targets.
WebMay 2, 2024 · GPR146 was first identified when searching in genome databases for orthologues of the Rhodopsin family of human GPCRs in 2005. 10 Then, GPR146 was demonstrated to be part of the C-peptide signalling complex and provided a platform for the elucidation of the C-peptide signalosome. 11 C-peptide and GPR146 have been found to … WebSep 1, 2024 · GPR146 is a potential new therapeutic target for lipid lowering. Nat Rev Cardiol. 2024; 17:132–133. doi: 10.1038/s41569-019-0328-5 Crossref Google Scholar; 8. Yosten GL, Kolar GR, Redlinger LJ, Samson WK. Evidence for an interaction between proinsulin C-peptide and GPR146. J Endocrinol.
WebProduct name Anti-GPCR GPR146 antibody See all GPCR GPR146 primary antibodies Description Rabbit polyclonal to GPCR GPR146 Host species Rabbit Tested applications Suitable for: WB more details Species reactivity Reacts with: Human Predicted to work with: Monkey Immunogen WebJun 3, 2024 · Research Highlight. Recently, Yu et al. [ 1] revealed that G protein-coupled receptor 146 (GPR146) exerts a detrimental effect on the regulation of systemic …
Web3 hours ago · TOTUM-070 is a patented polyphenol-rich blend of five different plant extracts showing separately a latent effect on lipid metabolism and potential synergistic properties. In this study, we investigated the health benefit of such a formula. Using a preclinical model of high fat diet, TOTUM-070 (3 g/kg of body weight) limited the HFD-induced hyperlipemia …
WebStimulation with C-peptide induced internalization of GPR146, and punctate colocalization was observed between C-peptide and GPR146 on KATOIII cell membranes. These … ram fletcherWebNov 11, 2024 · Further mechanistic studies showed that GPR146 promotes postprandial activity of hepatic sterol regulatory element binding protein 2 (SREBP2) through activation of extracellular signal-regulated... ramflowWebNov 27, 2024 · Here we demonstrate that orphan G protein-coupled receptor 146 (GPR146) promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) … ramfles phone numberWebSeveral studies have indicated that GPR146 is a putative receptor for C-peptide [49]. Previous reports have demonstrated that GPR146 plays a vital role in the regulation of plasma cholesterol... overhead scarfWebOct 23, 2024 · GPR146 G protein-coupled receptor 146 Gene ID: 115330, updated on 23-Oct-2024 Gene type: protein coding Also known as: PGR8 Go to complete Gene record … overhead scanner cameraWebJul 1, 2024 · GPR146 C-peptide Dynamic mass redistribution β-Arrestin Fluorescence microscopy The connecting chain of proinsulin, C-peptide, is a 31-mer polypeptide that has shown positive effects on several aspects of diabetic kidney disease (DKD) and has therefore received interest as a potential treatment. overhead scanner reviewsWebG Protein-coupled Receptor (GPCR) Deorphanization. We developed the first – and we believe the only – high-throughput system to identify synthetic ligands, including … ramflex mondo flooring