Glut4 molecular weight
WebApr 12, 2024 · Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals, and OPE exposure may be associated with type 2 diabetes (T2D). However, greater knowledge regarding the biomolecular intermediators underlying the impact of OPEs on T2D in humans are needed to understand biological etiology. … WebJun 18, 2014 · Western blotting using polyclonal antibodies against coho salmon GLUT4 (okGLUT4) confirmed that the molecular weight of native GLUT4 in adipose tissue and skeletal muscle cells from salmonid species was approximately 50 kDa [31,32]. Comparison of human GLUT4 and fish GLUT4 proteins evidences a relatively high degree of …
Glut4 molecular weight
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WebApr 13, 2024 · The Glucose Transporter type 4 (GLUT4), encoded by the Solute Carrier Family 2 Member 4 (Slc2a4) gene, plays a pivotal role in skeletal muscle, adipose tissue, and brain glucose uptake [12, 13]. Some stimuli, such as physical exercise or eating positively affect the translocation of GLUT4 to the cell membrane, facilitating glucose … Web1/100 - 1/1000. Predicted molecular weight: 54 kDa. IHC-P 1/100 - 1/500. Flow Cyt (Intra) 1/100. Target. Function. Insulin-regulated facilitative glucose transporter. Tissue specificity. ... Anti-Glucose Transporter GLUT4 …
WebOct 15, 2024 · The GLUT4 cDNA sequence of the blunt snout bream has an open reading frame of 1518 bp and encodes 505 amino acids . GLUT4 had a theoretical isoelectric point and molecular weight were 6.41 and 55.47 kDa, respectively. WebOct 15, 2024 · Its theoretical isoelectric point and molecular weight was 6.41 and 55.47 kDa, respectively. A comparison of these characteristics with BLASTP results from the NCBI database showed that MaGLUT4 had the highest homology with Cypriniformes fish, with MaGLUT4 and GLUT4 of other Cypriniformes clustered in the phylogenetic tree with …
WebSkeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is … WebSep 2, 2012 · GLUT4 has long been known to be an insulin responsive glucose transporter. Regulation of GLUT4 has been a major focus of research on the cause and prevention of …
WebDec 15, 2009 · Glut4. Since its discovery as a distinct glucose transporter isoform in the late 1980s by James et al. ... but Glut7 is most likely involved in the dietary absorption of one …
WebMar 1, 2001 · Labeled GLUT4 protein was quantified by integrating the area under the 3 H peak corresponding to the 45-kDa molecular weight marker and subtracting the average background radioactivity in the gel. ... Total GLUT4 content in skeletal muscle of NTG and TG mice is expressed as a percentage of a 50-μg rat skeletal muscle plasma membrane … flexible cloth tapeWebAug 1, 2001 · Insulin resistance represents a major pathogenic impairment in the development of type 2 diabetes (1,2).In humans and rodents, skeletal muscle is the primary site of insulin-mediated glucose disposal ().Insulin increases glucose uptake in muscle by eliciting GLUT4 translocation from an intracellular storage site to both the plasma … flexible clothingWebGlut4/SLC2A4 Protein Molecular Weight & PI . Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4) Homo sapiens (Human). The parameters … flexible commissioning toolkitWebApr 4, 2007 · GLUT4 is one of 13 sugar transporter proteins (GLUT1-GLUT12, and HMIT) encoded in the human genome (Joost and Thorens, 2001, Wood and Trayhurn, 2003) that catalyzes hexose transport across cell membranes through an ATP-independent, facilitative diffusion mechanism (Hruz and Mueckler, 2001).These sugar transporters display … chelsea harrellWebJun 1, 2001 · Human skeletal muscle consists of slow-twitch oxidative (type 1) and fast-twitch nonoxidative (type 2) fibers. Slow-twitch fibers are both more insulin-sensitive and more insulin-responsive compared with fast-twitch fibers (13,14,15,16).Fast-twitch fibers are more sensitive to contraction than slow-twitch fibers ().We have recently developed a … chelsea harper tyler txWebOct 5, 2024 · Insulin stimulates glucose uptake in adipose tissue and skeletal muscle by inducing plasma membrane translocation of the glucose transporter GLUT4. Although the small GTPase Rac1 is a key regulator downstream of phosphoinositide 3-kinase (PI3K) and the protein kinase Akt2 in skeletal muscle, it remains unclear whether Rac1 also … flexible comfort flatform sandalsWebMolecular studies have shown that 1-DNJ increases the phosphorylation of Akt, PI3K, IRS1 and IR-β in skeletal muscle and finally leads to an increase in membrane displacement of GLUT4, making it possible for 1-DNJ in mulberry leaves to improve insulin resistance and reduce blood glucose (Liu et al., 2015). flexible comfortable black work boots