WebBMT CTN 1506 A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3 Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients with FLT3/ITD AML. Cancer Answer Line 866.223.8100; Details. IRB Study Number 17-1147 WebNov 5, 2024 · During consolidation, patients received ≤3 cycles of cytarabine (1.5 g/m 2 every 12 hours; Days 1, 3, and 5) and gilteritinib (Days 1-14 for parts 1-3; Days 1-56 for part 4) at the induction dose. Gilteritinib was given once daily in 28-day cycles for up to 26 cycles as maintenance therapy (maintenance phase is still ongoing).
A Trial of the FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor
WebJul 1, 2024 · On November 28, 2024, the FDA approved gilteritinib (Xospata; Astellas), a small-molecule FMS-like tyrosine kinase 3 (FLT3) inhibitor, for treatment of relapsed or … WebJul 1, 2024 · Abstract. On November 28, 2024, the FDA approved gilteritinib (Xospata; Astellas), a small-molecule FMS-like tyrosine kinase 3 (FLT3) inhibitor, for treatment of relapsed or refractory acute myeloid leukemia with a FLT3 mutation as detected by an FDA-approved test. In the ADMIRAL study, patients were randomized 2:1 to receive … hp gas bhandup
Triplet therapy with venetoclax, FLT3 inhibitor and decitabine …
WebAug 21, 2024 · The MORPHO trial is a randomized, double-blind, placebo-controlled, multi-center trial that compares gilteritinib to placebo as maintenance therapy over a period of two years following hematopoietic stem cell transplant (HCT) in patients with FLT3 internal tandem duplication (ITD) mutation-positive (FLT3/ITD+) acute myeloid leukemia (AML) … WebAn official website of the United States government Menu. Search Search WebApr 24, 2024 · In fact, this assay will be used to measure MRD as a secondary end point in a pivotal trial of the novel FLT3 inhibitor gilteritinib administered as maintenance therapy after allogeneic HSCT (BMT-CTN 1506/Morpho; NCT02997202). The primary end point of BMT-CTN1506 is relapse-free survival, which necessitates a prolonged clinical study. festekbolt