WebJun 13, 2005 · DrugBank Accession Number. DB01213. Background. Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic … WebDec 15, 2009 · Methanol and ethylene glycol. Methanol and ethylene glycol poisoning results in a severe high anion gap metabolic acidosis. Both are metabolized via the enzyme alcohol dehydrogenase resulting in formation of acids (formic, glycolic, and oxalic, respectively) which accumulate in the body and are responsible for neurological damage …
Alcohol Toxicity Clinical Presentation - Medscape
WebJan 1, 2014 · Ethylene glycol (EG) and methanol poisoning can cause life-threatening complications. Toxicity of EG and methanol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), which can lead to metabolic acidosis, renal failure (in EG poisoning), blindness (in methanol poisoning) and death. WebDiagnosis of ethylene glycol poisoning usually depends on the detection of the toxicant or toxic metabolites in serum or plasma. The most commonly used analytic methods for detection and quantification of ethylene glycol use gas chromatography (GC) coupled to flame ionization detection (FID) or mass spectrometric detectors [Juenke et al. 2011]. easy game level 149
Ethylene glycol or methanol intoxication: Which antidote
WebThe focus of this article is poisoning from organophosphates, cyanide, ethylene glycol and methanol, laundry and cleaning products, mushrooms and plants, and carbon dioxide. In the United States, if poisoning is suspected, Poison Control (available 24/7 at 1-800-222-1222 ) should be contacted immediately to obtain information from specialists ... WebAccidental or intentional ingestion of substances containing methanol and ethylene glycol can result in death, and some survivors are left with blindness, renal dysfunction, and chronic brain injury. However, even in large ingestions, a favorable outcome is possible if the patient arrives at the hospital early enough and the poisoning is ... easy game level 132