Ddit4 hypoxia
WebNov 23, 2016 · DDIT4 protein, human HIF1A protein, human Hypoxia-Inducible Factor 1, alpha Subunit Transcription Factors MTOR protein, human TOR Serine-Threonine Kinases Grant support Department of Health/United Kingdom
Ddit4 hypoxia
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WebApr 14, 2024 · Enhancer RNAs (eRNAs) are non-coding RNAs (ncRNAs) transcribed in enhancer regions. They play an important role in transcriptional regulation, mainly during cellular differentiation. eRNAs are tightly tissue- and cell-type specific and are induced by specific stimuli, activating promoters of target genes in turn. eRNAs usually have a very … WebMar 23, 2024 · DDIT4 positively regulates the mTOR inhibiting tuberous sclerosis complex (TCS1/2) 22, and is upregulated in response to various cellular stresses, including DNA damage 23, hypoxia 24, 25 and...
WebJul 1, 2024 · Purpose: To assess how DNA damage-inducible transcript 4 (DDIT4) and autophagic flux are altered in dry eye disease and reveal the underlying mechanisms. … WebJan 22, 2024 · DDIT4 is a highly conserved stress response protein whose expression is affected by various cellular stresses, such as hypoxia, DNA damage, energy stress, nutrient depletion, and endoplasmic reticulum stress [ 8 ].
WebXiaoyu Deng is an academic researcher from Zhengzhou University. The author has contributed to research in topic(s): Nasopharyngeal carcinoma & DDIT4. The author has co-authored 2 publication(s). WebJan 8, 2024 · DDIT4 stabilizes the formation of tuberous sclerosis complex 1 (TSC1) and 2 (TSC2) to inhibit activation of the mammalian target of rapamycin (mTOR) complex (mTORC)-1, leading to cell death [ 7 ]. It seems that DDIT4 may have a tumor-suppressive role in cancer progression.
WebRegulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it …
WebAug 8, 2016 · The hypoxia response program in intestinal epithelial cells limits local inflammation 12, 27, 28, providing counter-regulation against activated neutrophils 27. Analogous to this, the... marionkids.comWebNov 23, 2016 · Furthermore we show that DDIT4 is activated downstream of HIF1α in response to hypoxia and p53 pathways. In addition, we demonstrate that DDIT4 activity … marion kansas school district calendarWebJun 26, 2024 · Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia, strongly … marion kieffer orthophonisteWebOur DDIT4 Antibodies can be used in a variety of model species: Human, Mouse, Rat. Use the list below to choose the DDIT4 Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Choose from our DDIT4 polyclonal antibodies. marion kentucky sheriff officeWebDec 2, 2024 · In comparison, DDIT4 overexpression showed a negative correlation with immune score and infiltrations of several immune cells. DDIT4 played crucial roles in the differentiation of CAFs and T cells. Collectively, this study demonstrates that DDIT4 contributes a critical role in HNSCC progression. naturschoenes shopWebJun 3, 2024 · Three genes (WAS, SETX and DDIT4) were related to DNA repair, indicating that DNA stability may be influenced by hypoxia in TNBC. Conclusions Our results demonstrate that CAIX appears to be a significant hypoxia-inducible molecular marker and increased CAIX protein levels are independently associated with poor survival in TNBC. marion kiki roberts deathWebFeb 12, 2016 · DDIT4 expression is low in physiological condition but is induced and plays an important role in hypoxia, oxidative stress, DNA damage, and other stimuli [13, 14]. It has been reported that DDIT4 can induce hypoxia-triggered apoptosis of differentiated PC12 cells through activation of the caspase pathway . naturrum thyborøn