Ctrp family: linking immunity to metabolism
WebLinking Immunity to Metabolism FIGURE 1: Structural organization of the CTRP family members. a) Domain structure of a CTRP monomeric protein. b) Homotrimeric CTRP protein structure. CTRP monomeric proteins form homotrimeric or/and heterotrimeric protein structures. c) Higher-order protein structures of CTRP trimers. WebIt is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic diseases such as visceral obesity and type 2 diabetes are characterized by high levels of proinflammatory cytokines. Metabolism and immunity …
Ctrp family: linking immunity to metabolism
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WebJan 17, 2012 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined … WebMar 16, 2016 · Recent studies have shown that the CTRP family of proteins, paralogs of adiponectin, play a crucial role in the regulation of systemic metabolism and innate immunity [18,19]. CTRP-1 to CTRP-15 show remarkable similarities in their structural and biochemical properties compared to adiponectin [18].
WebAug 10, 2024 · Previous studies have demonstrated that CTRP family members are involved in the regulation of multiple physiological and pathological processes, including glucose and lipid metabolism, inflammation ... Schäffler A and Buechler C: CTRP family: Linking immunity to metabolism. Trends Endocrinol Metab. 23:194–204. 2012. WebSep 1, 2024 · CTRP1 plays an important role in regulating body energy homeostasis and sensitivity to insulin. Studies on animal models have shown that it lowers the concentration of glucose. Elevated concentrations of CTRP1 …
WebSep 21, 2024 · Tumors of the digestive system have always received attention, and their occurrence and development are regulated by various mechanisms such as inflammation and immunity, glucose and lipid metabolism, and tumor angiogenesis. Complement Clq/TNF‑related protein 6 (CTRP6) is a member of the CTRP family; it is widely … WebApr 1, 2012 · The term CTRP, originally introduced by Harvey Lodish and coworkers, describes a new family of secreted proteins that were cloned on the basis of sequence …
WebJul 22, 2016 · Shareable Link. Use the link below to share a full-text version of this article with your friends and colleagues. ... as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors. ... but their important regulatory functions in metabolism, immune defence and, more recently, cancer is …
WebSep 4, 2024 · This family, originally identified by Lodish and coworkers, is a highly conserved family consisting of secreted proteins that were cloned on the basis of an adiponectin homology sequence.1Up to now, 15 members have been identified in CTRP superfamily (CTRP1–CTRP15) (Figure 1). howdens sofia rose handleWebOct 7, 2024 · CTRP family is a class of chemical hormones mainly secreted by adipose tissue. It is also widely expressed in various organs and tissues and exerts … how many ronaldos are thereWebDec 29, 2016 · CTRP13 is another member of the CTRP family, which is mainly expressed in adipose tissue and can increase insulin-mediated glucose uptake and reduce … howdens small kitchen ideasWebSep 4, 2024 · This family, originally identified by Lodish and coworkers, is a highly conserved family consisting of secreted proteins that were cloned on the basis of an adiponectin homology sequence. 1 Up... howdens smart latchWebMay 17, 2024 · Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ... Shareable Link. Use the link below to share a full-text version of this article with your friends and colleagues. ... C1q/TNF-related proteins (CTRP1-15) constitute a conserved group of secreted proteins of the C1q … how many roofing nails are in a 50 pound boxWebJan 17, 2012 · The C1q/ TNF-related protein (CTRP) family is involved in the body's metabolism and immunity (Schäffler and Buechler, 2012). CTRPs play important roles … howdens slough ukWebNov 22, 2024 · In recent years, some CTRP family proteins, such as CTRP5, CTRP6, and CTRP15, have been found to be associated with metabolic disorders, but there are very few reports about CTRP7 and its ... how many roofing battens in a pack